More on target with protein phosphorylation: conferring specificity by location

Trends Biochem Sci. 1996 Aug;21(8):312-5.


One important regulatory mechanism in the control of phosphorylation events is the subcellular location of phosphatases of kinases. Several serine/threonine phosphatases and kinases have now been shown to be associated with targeting subunits; these contribute to the organization and specificity of signal transduction pathways by favoring the accessibility of their enzymes to certain substrates.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Humans
  • Models, Biological
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation
  • Protein Kinase C / metabolism*
  • Signal Transduction
  • Substrate Specificity


  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C
  • Phosphoprotein Phosphatases