Genetic epidemiology of the three predominant abnormal hemoglobins in India

J Assoc Physicians India. 1996 Jan;44(1):25-8.


Hemoglobinopathies in India are Important public health problems. Of the several abnormal of hemoglobin molecules, there are three variants, viz. Sickle cell, hemoglobin E and hemoglobin D which are predominantly prevalent in India. The cumulative gene frequencies of these hemoglobins have been found to be 5.35% in India. The average gene frequency of sickle cell and hemoglobin D in India has been observed to be 4.3% and 0.86%, respectively. In the North Eastern region of India, the gene frequency of hemoglobin E is 10.9%. Gene frequencies and spatial distribution of the predominant abnormal hemoglobins in India have been discussed in variance with the previous generalisations.

MeSH terms

  • Adult
  • Anemia, Sickle Cell / epidemiology
  • Anemia, Sickle Cell / genetics
  • Ethnicity / genetics
  • Gene Frequency
  • Hemoglobin E / genetics
  • Hemoglobin, Sickle / genetics
  • Hemoglobinopathies / epidemiology
  • Hemoglobinopathies / genetics
  • Hemoglobins, Abnormal / genetics*
  • Humans
  • India / epidemiology
  • Molecular Epidemiology
  • Prevalence


  • Hemoglobin, Sickle
  • Hemoglobins, Abnormal
  • hemoglobin D
  • Hemoglobin E