Characterization and interpretation of electrical signals from random networks of cultured neurons

Technol Health Care. 1996 Apr;4(1):77-86.


The main purpose of this paper is to describe several software tools specifically adapted to characterize the electrophysiological behavior of a population of neurons coupled to a planar array of microtransducers by analyzing the recorded signals. Both graphic and signal processing tools are considered. They include: image analysis of the neuronal network topology, peak detection procedure, multi-graphics visualization, spike classification, cross-correlation, interspike and interbursting interval analysis. These tools are utilized to characterize changes induced in the electrophysiological behavior of populations of cultured neurons by modifications to the medium-culture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Chick Embryo
  • Computer Graphics
  • Culture Media
  • Electrophysiology*
  • Image Interpretation, Computer-Assisted
  • In Vitro Techniques
  • Microelectrodes
  • Nerve Net / physiology*
  • Signal Processing, Computer-Assisted*
  • Software Design
  • Software*


  • Culture Media