Renal functional reserve in kidney donors assessed in different settings using scintigraphy

Nephron. 1996;73(2):154-7. doi: 10.1159/000189032.

Abstract

Glomerular filtration rate (GFR) was measured in 9 voluntary male kidney donors by scintigraphy. In the basal state, the mean GFR was 96.1 +/- 22 ml/min/1.73 m2. Four weeks after donor nephrectomy, the GFR of the remaining kidney had increased by 22.8 +/- 20.7% (p < 0.05). A protein meal given at this time failed to significantly augment the GFR. The GFR of the grafted kidney increased by 59.7 +/- 24.4% after 6 months (p < 0.01). Renal functional reserve was thus demonstrated in the remaining kidney and the allograft, though a further reserve could not be elicited in the remaining kidney.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dietary Proteins / metabolism
  • Glomerular Filtration Rate / physiology
  • Humans
  • Kidney / diagnostic imaging*
  • Kidney Function Tests / methods*
  • Kidney Transplantation / physiology
  • Living Donors*
  • Male
  • Nephrectomy
  • Radionuclide Imaging
  • Technetium Tc 99m Pentetate

Substances

  • Dietary Proteins
  • Technetium Tc 99m Pentetate