Nicotine cue: lack of effect of the alpha 7 nicotinic receptor antagonist methyllycaconitine

Eur J Pharmacol. 1996 Apr 22;301(1-3):1-5. doi: 10.1016/0014-2999(96)00010-6.


To assess the role of the alpha 7 neuronal nicotinic acetylcholine receptor in the discriminative stimulus properties of (-)-nicotine, this study investigated the ability of the alpha 7 receptor antagonist methyllycaconitine to modulate the nicotine cue. In rats trained to discriminate (-)-nicotine from saline, intraperitoneal injections of methyllycaconitine neither induced nor blocked the nicotine cue. Intracerebroventricular administration of methyllycaconitine, neither potentiated nor blocked the effect of (-)-nicotine. On the other hand, intracerebroventricular injections of mecamylamine blocked the nicotine cue. The available evidence indicate that the nicotinic acetylcholine receptors in the brain blocked by methyllycaconitine, those presumably containing alpha 7 subunits, do not participate in the expression of the discriminative stimulus properties of (-)-nicotine.

MeSH terms

  • Aconitine / analogs & derivatives*
  • Aconitine / pharmacology
  • Animals
  • Conditioning, Operant / drug effects
  • Cues*
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Male
  • Mecamylamine / pharmacology
  • Nicotine / pharmacology*
  • Nicotinic Agonists / pharmacology*
  • Nicotinic Antagonists / administration & dosage
  • Nicotinic Antagonists / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, Nicotinic / drug effects*


  • Nicotinic Agonists
  • Nicotinic Antagonists
  • Receptors, Nicotinic
  • methyllycaconitine
  • Mecamylamine
  • Nicotine
  • Aconitine