Correlation between colposcopically directed biopsy and cervical loop excision

Gynecol Oncol. 1996 Mar;60(3):400-3. doi: 10.1006/gyno.1996.0062.


Colposcopy is standard for diagnosis of cervical cancer precursors, but the development of diathermy loop electrodes for excision of the cervical transformation zone offers a technique for validation. Loop excision of the transformation zone was performed for 47 consecutive women with dysplasia in colposcopically directed biopsies using 20 x 8-mm electrodes. Specimens were marked for orientation and serially sectioned. All pathology material was reviewed. Although 28% of women had disappearance of dysplasia at the biopsy site, only 9% had no dysplasia in the transformation zone. Half of the women with CIN 1 on directed biopsy had high-grade lesions found in loop excision specimens. Significant discrepancies may be found between the results of colposcopically directed biopsy and loop excision.

MeSH terms

  • Adult
  • Biopsy / methods*
  • Cervical Intraepithelial Neoplasia / pathology
  • Cervix Uteri / pathology*
  • Cervix Uteri / surgery*
  • Colposcopy*
  • Diathermy
  • Female
  • Humans
  • Radiosurgery*
  • Uterine Cervical Dysplasia / pathology*
  • Uterine Cervical Neoplasms / pathology