15-Hydroxyprostaglandin dehydrogenase

J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):313-9. doi: 10.1016/0929-7855(95)00040-w.


Relatively little is known about how 15-PGDH activity is regulated. Changes in 15-PGDH activity have been reported in response to physiological changes brought about by aging, pregnancy, hormonal changes, hypertension and smoking. In addition a large number of drugs have been shown to affect 15-PGDH activity both in vivo and in vitro. The availability of the 15-PGDH cDNA will be a valuable tool for studying how this enzyme is regulated. Isolation of the genomic DNA with its promoter regions has not yet been reported.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Cloning, Molecular
  • Female
  • Humans
  • Hydroxyprostaglandin Dehydrogenases / chemistry
  • Hydroxyprostaglandin Dehydrogenases / isolation & purification
  • Hydroxyprostaglandin Dehydrogenases / metabolism*
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • NAD / metabolism
  • Placenta / metabolism
  • Pregnancy
  • Prostaglandins / metabolism


  • Prostaglandins
  • NAD
  • Hydroxyprostaglandin Dehydrogenases
  • 15-hydroxyprostaglandin dehydrogenase