Abstract
We describe the case of a 32-year-old splenectomised man with severe Wegener's granulomatosis which was refractory to conventional treatment with oral cyclophosphamide and prednisolone. Remission was temporarily induced only with plasma exchange or i.v. immunoglobulin. Because of frequent relapses of the disease and cyclophosphamide side effects, he was started on treatment with cyclosporin-A and a long lasting remission was achieved.
MeSH terms
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Adult
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Cyclophosphamide / therapeutic use
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Cyclosporine / administration & dosage
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Cyclosporine / therapeutic use*
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Follow-Up Studies
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Glucocorticoids / therapeutic use
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Granulomatosis with Polyangiitis / diagnosis
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Granulomatosis with Polyangiitis / drug therapy*
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use*
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Male
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Plasma Exchange
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Prednisolone / therapeutic use
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Recurrence
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Remission Induction
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Splenectomy
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Tomography, X-Ray Computed
Substances
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Glucocorticoids
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Immunosuppressive Agents
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Cyclosporine
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Cyclophosphamide
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Prednisolone