Tonkinecin, a novel bioactive annonaceous acetogenin from Uvaria tonkinesis

J Nat Prod. 1996 May;59(5):507-9. doi: 10.1021/np960321h.

Abstract

A novel bioactive monotetrahydrofuran acetogenin named tonkinecin (1) and two known compounds, uvariamicins I and II, have been isolated from the roots of Uvaria tonkinesis. The structure of 1 was elucidated using spectral methods and its absolute stereochemistry established by 1H-NMR experiments utilizing Mosher ester methodology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • China
  • Drug Screening Assays, Antitumor
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • HL-60 Cells
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Furans
  • Lactones
  • tonkinecin