Abstract
A novel bioactive monotetrahydrofuran acetogenin named tonkinecin (1) and two known compounds, uvariamicins I and II, have been isolated from the roots of Uvaria tonkinesis. The structure of 1 was elucidated using spectral methods and its absolute stereochemistry established by 1H-NMR experiments utilizing Mosher ester methodology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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China
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Drug Screening Assays, Antitumor
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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HL-60 Cells
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Humans
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Furans
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Lactones
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tonkinecin