Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

J Nat Prod. 1996 May;59(5):525-7. doi: 10.1021/np960149h.


An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • China
  • HIV Reverse Transcriptase
  • Humans
  • Magnetic Resonance Spectroscopy
  • Nucleic Acid Synthesis Inhibitors
  • Plants, Medicinal / chemistry*
  • RNA-Directed DNA Polymerase / metabolism*
  • Reverse Transcriptase Inhibitors / isolation & purification*
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology


  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • Triterpenes
  • nigranoic acid
  • HIV Reverse Transcriptase
  • RNA-Directed DNA Polymerase