Antiinflammatory C-glucosyl chromone from Aloe barbadensis

J Nat Prod. 1996 May;59(5):541-3. doi: 10.1021/np9601519.

Abstract

A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Chromatography, High Pressure Liquid
  • Chromones / isolation & purification*
  • Chromones / pharmacology
  • Croton Oil
  • Ear, External / pathology
  • Gas Chromatography-Mass Spectrometry
  • Inflammation / chemically induced
  • Inflammation / pathology
  • Inflammation / prevention & control
  • Magnetic Resonance Spectroscopy
  • Male
  • Mass Spectrometry
  • Mice
  • Mice, Inbred BALB C
  • Plants, Medicinal*
  • Spectrophotometry, Ultraviolet

Substances

  • 8-(2-O-cinnamoyl(glucopyranosyl))-2-(2-hydroxypropyl)-7-methoxy-5-methylchromone
  • Anti-Inflammatory Agents, Non-Steroidal
  • Chromones
  • Croton Oil