Benign gynecologic conditions associated with a CA-125 level > 1,000 U/mL. A case report

J Reprod Med. 1996 Mar;41(3):179-82.


Background: CA-125 was initially investigated as a marker of ovarian cancer. However, various studies have noted that it can be minimally elevated in benign conditions.

Case: A case of CA-125 > 1,000 U/mL was associated with benign gynecologic conditions. A 37-year-old woman with a history of endometriosis and premature ovarian failure underwent hormonal therapy for donor in vitro fertilization. After an unsuccessful cycle, severe dysmenorrhea developed. Investigation revealed a CA-125 level of 1,036 U/mL and a uterine mass. On exploratory laparotomy, cystic adenomyosis and uterine endometriosis was found. After excision of these areas, the CA-125 levels returned to normal. In this case, cystic adenomyosis and endometriosis of the uterine serosa were responsible for the elevated CA-125 level.

Conclusion: Very high levels of CA-125 are not always associated with a malignant process.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers / blood
  • CA-125 Antigen / blood*
  • Endometriosis / blood
  • Endometriosis / immunology*
  • Female
  • Fertilization in Vitro
  • Gonadal Steroid Hormones / administration & dosage
  • Humans
  • Primary Ovarian Insufficiency / immunology
  • Uterine Diseases / blood
  • Uterine Diseases / immunology*


  • Biomarkers
  • CA-125 Antigen
  • Gonadal Steroid Hormones