HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors

Am J Pathol. 1996 Sep;149(3):775-9.


Cytogenetically visible aberrations of chromosomal region 12q14-15 in a variety of frequent benign human tumors reflect rearrangements of the HMGI-C gene. The mechanisms by which the HMGI-C gene contributes to tumorigenesis are mostly unknown, although frequently aberrant transcripts containing exons 1 to 3 of HMGI-C and ectopic sequences from other genes due to breaks within the third intron of HMGI-C are detectable. This is the first report analyzing human tissue samples mainly of mesenchymal origin by a highly sensitive polymerase-chain-reaction-based approach detecting HMGI-C expression. We found HMGI-C expression in embryonic tissue but no expression in any of several adult tissues tested except for two myometrial tissues. These data suggest that HMGI-C is mainly expressed in human tissues during embryonal and fetal development. Thus, its particular role for tumor development may be due to the expression of at least exons 1 to 3 rather than to the formation of fusion transcripts.

MeSH terms

  • Adult
  • Aged
  • Base Sequence
  • Embryo, Mammalian / chemistry
  • Female
  • Gene Expression Regulation, Neoplastic / genetics*
  • HeLa Cells / physiology
  • High Mobility Group Proteins / genetics*
  • Humans
  • Infant, Newborn
  • Mesoderm / chemistry*
  • Middle Aged
  • Molecular Sequence Data
  • Myometrium / chemistry
  • Neoplasms / genetics*
  • Polymerase Chain Reaction / methods
  • Pregnancy
  • Reference Values
  • Sensitivity and Specificity
  • Tumor Cells, Cultured


  • High Mobility Group Proteins