A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma

Immunogenetics. 1996;44(5):323-30. doi: 10.1007/BF02602776.


Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm / analysis
  • Antigens, Neoplasm / genetics*
  • Antigens, Neoplasm / immunology
  • Base Sequence
  • Carcinoma, Renal Cell / immunology*
  • Cell Line, Transformed
  • Chlorocebus aethiops
  • DNA, Complementary / genetics
  • Eye Proteins / analysis
  • Eye Proteins / genetics*
  • Eye Proteins / immunology
  • Genes*
  • HLA-B7 Antigen / immunology
  • Humans
  • Kidney Neoplasms / immunology*
  • Mitogen-Activated Protein Kinases
  • Molecular Sequence Data
  • Neoplasms / immunology
  • Retina / immunology
  • Sequence Alignment
  • Sequence Homology
  • T-Lymphocytes, Cytotoxic / immunology*
  • Transfection


  • Antigens, Neoplasm
  • DNA, Complementary
  • Eye Proteins
  • HLA-B7 Antigen
  • MOK protein, human
  • Mitogen-Activated Protein Kinases

Associated data

  • GENBANK/U46191
  • GENBANK/U46192
  • GENBANK/U46193
  • GENBANK/U46194