Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat

Metabolism. 1996 Sep;45(9):1056-8. doi: 10.1016/s0026-0495(96)90001-3.


Hepatic apolipoprotein (apo) B RNA editing was examined in the genetically obese hyperinsulinemic and hypertriglyceridemic Zucker rat. In obese Zucker rats, apo B RNA editing was increased 42% relative to that in lean controls. Correspondingly, the proportion of serum triglyceride-rich lipoprotein containing apo B48 increased 4.7-fold in the obese Zucker rat. Quantification of hepatic total apo B mRNA showed no difference between obese Zucker and lean control rats. In contrast, the hepatic mRNA encoding APOBEC-1, the catalytic subunit of the RNA editing activity, demonstrated an increased abundance of 1.8-fold in obese Zucker rats versus lean controls.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • APOBEC-1 Deaminase
  • Animals
  • Apolipoproteins B / genetics*
  • Cytidine Deaminase / genetics
  • Cytidine Deaminase / metabolism
  • Disease Models, Animal
  • Hyperinsulinism / blood
  • Hyperinsulinism / genetics
  • Hyperinsulinism / metabolism
  • Hypertriglyceridemia / blood
  • Hypertriglyceridemia / genetics
  • Hypertriglyceridemia / metabolism
  • Insulin Resistance / genetics
  • Liver / metabolism*
  • Male
  • Obesity / genetics
  • Obesity / metabolism*
  • RNA Editing*
  • RNA, Messenger / genetics
  • Rats
  • Rats, Zucker


  • Apolipoproteins B
  • RNA, Messenger
  • AICDA (activation-induced cytidine deaminase)
  • APOBEC-1 Deaminase
  • Apobec1 protein, rat
  • Cytidine Deaminase