Types of methicillin-resistant Staphylococcus aureus associated with high mortality in patients with bacteremia

Eur J Clin Microbiol Infect Dis. 1996 Apr;15(4):340-3. doi: 10.1007/BF01695669.

Abstract

Forty-seven strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from 47 patients with bacteremia were analyzed by chromosomal DNA digestion pattern using pulsed-field gel electrophoresis and evaluated for serological coagulase type, enterotoxin type, and toxic shock syndrome toxin-1 production. The mortality rate was significantly higher in the older patients (> or = 51 years of age) than in the younger patients (< or = 50 years of age) (50% vs. 4%, p = 0.0007). Methicillin-resistant Staphylococcus aureus strains of serological coagulase type II were more likely to be associated with mortality in older patients than were strains of the other types (p = 0.037).

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteremia / microbiology*
  • Bacteremia / mortality*
  • Bacterial Toxins*
  • Child
  • Child, Preschool
  • Coagulase / metabolism
  • Enterotoxins / metabolism
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Methicillin Resistance*
  • Middle Aged
  • Restriction Mapping
  • Risk Factors
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / mortality*
  • Staphylococcus aureus / classification*
  • Staphylococcus aureus / metabolism
  • Superantigens*

Substances

  • Bacterial Toxins
  • Coagulase
  • Enterotoxins
  • Superantigens
  • enterotoxin F, Staphylococcal
  • enterotoxin C, staphylococcal