A greater understanding of the nature of schizophrenia, along with the continuing limitations of our current treatments, has refocused attention on the early course of psychosis in the form of early detection and intervention around onset. This issue of the Bulletin offers an indepth look at the knowledge, models, current data, and seminal clinical research programs that support why renewed interest in the late premorbid, prodromal, and onset phases of schizophrenia appears both timely and reasonable.