Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases

Nat Genet. 1996 Sep;14(1):42-9. doi: 10.1038/ng0996-42.


Silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated. We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects. SAS2, SAS3 and a Schizosaccharomyces pombe homologue are closely related to several human genes, including one associated with acute myeloid leukaemia arising from the recurrent translocation t(8;16)(p11;p13) and one implicated in HIV-1 Tat interactions. All of these genes encode proteins with an atypical zinc finger and well-conserved similarities to acetyltransferases. Sequence similarities and yeast mutant phenotypes suggest that SAS-like genes function in transcriptional regulation and cell-cycle exit and reveal novel connections between transcriptional silencing and human disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetyltransferases / genetics*
  • Acute Disease
  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA, Fungal
  • Enhancer Elements, Genetic
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Gene Products, tat / genetics
  • HIV-1 / genetics
  • Humans
  • Leukemia, Myeloid / genetics
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Resting Phase, Cell Cycle
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics*
  • Schizosaccharomyces / genetics
  • Sequence Homology, Amino Acid
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae*
  • Trans-Activators / genetics
  • Zinc Fingers / genetics*
  • tat Gene Products, Human Immunodeficiency Virus


  • DNA, Fungal
  • Fungal Proteins
  • Gene Products, tat
  • SIR1 protein, S cerevisiae
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Trans-Activators
  • tat Gene Products, Human Immunodeficiency Virus
  • Acetyltransferases

Associated data

  • GENBANK/L25608
  • GENBANK/M11621
  • GENBANK/M95912
  • GENBANK/U14548
  • GENBANK/U32686
  • GENBANK/U33335
  • GENBANK/U40989
  • GENBANK/U47321
  • GENBANK/U47742
  • GENBANK/X06117
  • GENBANK/X68628
  • GENBANK/Z23261
  • GENBANK/Z69795