Right-left asymmetry of D1- and D2-receptor density is lost in the basal ganglia of old rats

Brain Res. 1996 May 13;720(1-2):235-8. doi: 10.1016/0006-8993(96)00144-8.

Abstract

In the present study a left-right asymmetry in both D1- and D2-receptor density in the caudate-putamen nucleus is shown and a lateralisation of D2-receptor distribution in the accunbens nucleus is also described. In old animals in which D1- and D2-receptors density is decreased, the dopamine receptor asymmetries are lost.

MeSH terms

  • Aging / metabolism
  • Aging / physiology*
  • Animals
  • Autoradiography
  • Basal Ganglia / growth & development*
  • Basal Ganglia / metabolism*
  • Basal Ganglia / physiology
  • Benzazepines / metabolism
  • Caudate Nucleus / growth & development
  • Caudate Nucleus / metabolism
  • Caudate Nucleus / physiology
  • Dopamine Antagonists / metabolism
  • Functional Laterality / physiology*
  • Male
  • Nucleus Accumbens / growth & development
  • Nucleus Accumbens / metabolism
  • Nucleus Accumbens / physiology
  • Putamen / growth & development
  • Putamen / metabolism
  • Putamen / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / metabolism*
  • Receptors, Dopamine D2 / metabolism*
  • Sulpiride / metabolism

Substances

  • Benzazepines
  • Dopamine Antagonists
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Sulpiride