A light and electron microscopic study of GluR4-positive cells in human cerebral cortex

Neurosci Lett. 1996 May 31;210(2):107-10. doi: 10.1016/0304-3940(96)12685-9.


In human cerebral cortex non-pyramidal neurons were densely labelled for the glutamate receptor subunit GluR4, but pyramidal cells only lightly. Some small glial cells were also positive. They were either 'non-activated', with thin processes, or 'activated', with thicker stem processes with irregular outlines due to the presence of surface projections, and containing phagocytosed neuronal debris. GluR4-positive glia are putatively identified as oligodendrocyte precursor-like cells, and have similar light microscopic features to NG2 chondroitin sulphate proteoglycan-positive cells [Levine, J.M.,J. Neurosci., 14 (1994) 4716-4730].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cerebral Cortex / chemistry*
  • Cerebral Cortex / cytology
  • Female
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Neurons / chemistry
  • Neurons / ultrastructure
  • Oligodendroglia / chemistry
  • Oligodendroglia / ultrastructure
  • Receptors, Glutamate / analysis*
  • Receptors, Glutamate / chemistry


  • Receptors, Glutamate