Which cardiac potassium channel subtype is the preferable target for suppression of ventricular arrhythmias?

Pharmacol Ther. 1996;69(3):199-217. doi: 10.1016/0163-7258(95)02063-2.

Abstract

Prolongation of the cardiac action potential duration is the hallmark of Class III antiarrhythmic activity. Action potential duration prolongation may be achieved by several means: enhancement of inward current and, more commonly, blockade of one or more of the many outward currents that are carried by K+. However, it is far from clear whether blockade of one particular K+ channel is more efficacious than blockade of another. The objective of this review is to consider this question with particular reference to ischaemic heart disease, a condition for which effective prevention of ventricular arrhythmias continues to be sought.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / pharmacology*
  • Humans
  • Myocardial Ischemia / drug therapy
  • Myocardium / chemistry
  • Potassium Channels / classification
  • Potassium Channels / drug effects*
  • Potassium Channels / physiology
  • Ventricular Fibrillation / prevention & control*

Substances

  • Anti-Arrhythmia Agents
  • Potassium Channels