The neglected role of type I interferon in the T-cell response: implications for its clinical use

Immunol Today. 1996 Aug;17(8):369-72. doi: 10.1016/0167-5699(96)10027-X.


Originally described as an antiviral substance, type I interferon (IFN) was subsequently shown to exert multiple biological effects and is now the most frequently used cytokine in the treatment of some viral and neoplastic diseases. Although early studies described various effects on the immune system, the role of type I IFN as an immunoregulatory molecule has long been neglected. Here, Filippo Belardelli and Ion Gresser summarize recent experimental results on the interactions of type I IFN with T cells, which may prove important in its use in patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunotherapy, Active*
  • Interferon Type I / physiology*
  • Interferon Type I / therapeutic use*
  • Lymphocyte Activation / drug effects*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*


  • Interferon Type I