Non-malignant complications of coeliac disease

Acta Paediatr Suppl. 1996 May:412:68-75. doi: 10.1111/j.1651-2227.1996.tb14257.x.


Patients with coeliac disease are at increased risk of developing complications which increase morbidity and mortality. Emphasis on malignant complications has often overshadowed the non-malignant risks, which have received relatively little attention, although some of these can be very troublesome and even life-threatening. This article points out that a large population of unidentified or neglected coeliac patients is at potential risk. The challenge is to identify this group by case-finding or screening programmes in selected populations, so that they can be offered a gluten-free diet and other treatments which will not only improve general health but may also prevent or reduce the development of health problems. The non-malignant risks are outlined and bone and neuropsychiatric disturbances considered in more detail because of recent developments in these areas.

Publication types

  • Review

MeSH terms

  • Adult
  • Bone Diseases, Metabolic / etiology
  • Calcium Metabolism Disorders / complications
  • Calcium Metabolism Disorders / etiology
  • Celiac Disease / complications*
  • Celiac Disease / diet therapy
  • Celiac Disease / mortality
  • Child
  • Comorbidity
  • Depression / etiology
  • Diabetes Mellitus / epidemiology
  • Epilepsy / etiology
  • Growth / physiology
  • Humans
  • Infertility / etiology
  • Lymphatic Diseases / etiology
  • Mental Disorders / etiology
  • Nervous System Diseases / etiology
  • Rheumatic Diseases / epidemiology
  • Ulcer / etiology