Flies on steroids--Drosophila metamorphosis and the mechanisms of steroid hormone action

Trends Genet. 1996 Aug;12(8):306-10. doi: 10.1016/0168-9525(96)10032-9.


Recent studies have provided new insights into the molecular mechanisms by which the steroid hormone ecdysone triggers the larval-to-adult metamorphosis of Drosophila. Ecdysone-induced transcription factors activate large sets of secondary-response genes and provide the competence for subsequent regulatory responses to the hormone. It seems likely that similar hormone-triggered regulatory hierarchies exist in other higher organisms and that Drosophila is providing our first glimpses of the complexities of these gene networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila / genetics*
  • Drosophila / growth & development*
  • Ecdysone / physiology
  • Gene Expression Regulation, Developmental
  • Genes, Insect*
  • Insect Hormones / physiology*
  • Metamorphosis, Biological / genetics*
  • Steroids / biosynthesis
  • Steroids / physiology
  • Transcription Factors / biosynthesis


  • Insect Hormones
  • Steroids
  • Transcription Factors
  • Ecdysone