Hepatocyte growth factor and c-Met/hepatocyte growth factor receptor in pulmonary adenocarcinomas: an evaluation of their expression as prognostic markers

Oncology. Sep-Oct 1996;53(5):392-7. doi: 10.1159/000227594.


The expression of hepatocyte growth factor (HGF) and its receptor, c-Met, was investigated immunohistologically in tissue specimens of patients with a pulmonary adenocarcinoma. The prognosis was significantly worse in the HGF-positive or c-Met-positive patients than in the negative patients. Multivariate analysis showed that c-Met had a significant effect on the prognosis, whereas HGF did not. Our findings suggest that HGF and c-Met play an important role in tumor progression and that c-Met can be a useful prognostic marker for pulmonary adenocarcinomas.

MeSH terms

  • Adenocarcinoma / chemistry*
  • Adenocarcinoma / ultrastructure
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis*
  • Disease Progression
  • Epithelium / chemistry
  • Evaluation Studies as Topic
  • Female
  • Fibroblasts / chemistry
  • Hepatocyte Growth Factor / analysis*
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / chemistry*
  • Lung Neoplasms / ultrastructure
  • Male
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins c-met
  • Pulmonary Alveoli / chemistry
  • Receptor Protein-Tyrosine Kinases / analysis*


  • Biomarkers, Tumor
  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met
  • Receptor Protein-Tyrosine Kinases