Abstract
The genome of a novel human papillomavirus (HPV) type, HPV74, was cloned from an iatrogenically immunosuppressed woman with persisting low-grade vaginal intraepithelial neoplasia. HPV74 was found to be phylogenetically related to the low-risk HPV types 6, 11, 44, and 55. HPV74 or a variant of this type was found in specimens from three additional immunosuppressed women but not in about 3,000 anogenital specimens from immunocompetent patients.
MeSH terms
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Base Sequence
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Blotting, Southern
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Carcinoma in Situ / immunology
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Carcinoma in Situ / virology
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Cloning, Molecular
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DNA, Viral / genetics
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DNA, Viral / isolation & purification
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Female
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Genome, Viral
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Humans
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Immunocompromised Host*
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Kidney Transplantation / adverse effects
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Kidney Transplantation / immunology
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Molecular Sequence Data
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Open Reading Frames
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Papillomaviridae / classification*
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Papillomaviridae / genetics
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Papillomaviridae / isolation & purification
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Papillomavirus Infections / immunology
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Papillomavirus Infections / virology*
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Phylogeny
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Restriction Mapping
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
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Tumor Virus Infections / immunology
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Tumor Virus Infections / virology*
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Vaginal Neoplasms / immunology
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Vaginal Neoplasms / virology