Overuse syndromes are one of the most common occupational illnesses treated by primary care providers. Their pathophysiology parallels that of tenosynovitis. Occupational risk factors for overuse syndromes include repetition, high force, awkward joint posture, direct pressure, and vibration. Initial treatment is aimed at preventing fibrosis through rest, immobilization, and anti-inflammatory agents. Treatment must include identification and adjustment of occupational risk factors. Specific overuse syndromes are discussed, including tenosynovitis of the dorsal wrist extensor compartments and flexor tendons of the wrist, trigger finger, and carpal tunnel syndrome.