Interleukin-6 (IL-6) in patients with Behçet's disease

J Dermatol Sci. 1996 Mar;11(3):189-95. doi: 10.1016/0923-1811(95)00439-4.


We have examined the levels of interleukin-6 (IL-6) in plasma and supernatants of peripheral blood mononuclear cells (PBMC) from patients with Behçet's disease and healthy controls using a sensitive enzyme-linked immunosorbent assay (ELISA). Plasma IL-6 level was not detected in any subjects. The IL-6 concentrations in culture supernatants of patients with active Behçet's disease were significantly high compared with patients with inactive disease and healthy controls. Moreover, we investigated IL-6 gene expression in cultured PBMC from patients with Behçet's disease. IL-6 gene expression was enhanced in active patients compared with inactive patients. These results show that IL-6 may play a role in the pathogenesis of Behçet's disease.

MeSH terms

  • Adult
  • Base Sequence
  • Behcet Syndrome / blood
  • Behcet Syndrome / immunology*
  • Cells, Cultured
  • Female
  • Humans
  • Interleukin-6 / blood
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism*
  • Leukocytes, Mononuclear / metabolism
  • Male
  • Middle Aged
  • Molecular Sequence Data


  • Interleukin-6