Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region

P Malzac; M G Mattei; J Thibault; G Bruneau

doi:10.1007/BF02185772

Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region

Hum Genet. 1996 Mar;97(3):359-61. doi: 10.1007/BF02185772.

Authors

P Malzac¹, M G Mattei, J Thibault, G Bruneau

Affiliation

¹ Hopital d'Enfants de la Timone, Marseille, France.

PMID: 8786082
DOI: 10.1007/BF02185772

Abstract

Using a rat histidine decarboxylase (HDC) cDNA probe, we have mapped the HDC gene by in situ hybridization to the q15-q21 region of human chromosome 15 and to the E5-G region of murine chromosome 2. These localizations strengthen a syntenic group conserved between human chromosome 15 and mouse chromosome 2. The localization of the HDC gene on the human chromosome 15 map shows that it is not included within the Prader-Willi Syndrome region (PWCR).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping*
DNA Probes
Histidine Decarboxylase / genetics*
Humans
In Situ Hybridization
Mice
Prader-Willi Syndrome / genetics*

Substances

DNA Probes
Histidine Decarboxylase