A new polymethylmethacrylate membrane for hemodialysis

Int J Artif Organs. 1996 Apr;19(4):232-9.


High molecular weight (MW) solutes are not removed during conventional hemodialysis (HD), and their accumulation is thought to play a role in some long-term HD complications (anemia, bone and joint pain, neuropathy, itching). The present trial was conducted to evaluate the removal capacity during in vivo HD of a new polymethylmethacrylate (PMMA) membrane (Filtryzer BK-F, 1.3 m2) compared to conventional PMMA (BK-P, 1.6 m2) and to cellulose acetate (CA, 1.3 m2). BK-F dialyzers, with a pore size of 100 A degrees and 62% porosity, are designed to remove high MW substances. Ten stable anuric RDT patients (53 +/- 13 years) were treated for one week with each membrane in a randomized sequence. Plasma concentrations of creatinine, BUN and beta 2-microglobulin (beta 2-M) were measured before (b) and after (a) HD to determine the reduction rate for these substances (%). Beta 2-M concentration after HD was corrected for changes in distribution volume. Samples of spent dialysate were collected after 3 minutes, 120 minutes and at the end of HD sessions, and appropriately treated and concentrated for HPLC analysis. The reduction rate for BUN and creatinine was similar for the 3 membranes. BK-F showed a higher beta 2-M reduction rate than BK-P (p < 0.005) or CA (p < 0.0001). HPLC analysis of dialysate showed prevalent peaks < 4 kilodaltons (kDa) throughout HD for BK-P and CA. Solutes > 10 kDa were infrequently detected. Peak profile during HD with BK-F was quite different, showing a predominant peak > 50 kDa which also included albumin. However, albumin loss significantly decreased after 120 minutes and at the end of dialysis compared with the 3-minute values, and was lower than that reported in CAPD patients. With BK-F a peak of MW > 500 kDa was also detected which previous studies indicated as a range characterized by the presence of erythropoiesis inhibitors. Use of the BK-F membrane in HD could afford satisfactory removal of high MW substances, thereby preventing or controlling some long-term HD complications such as anemia or beta 2-M amyloid formation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Biocompatible Materials
  • Blood Urea Nitrogen
  • Cellulose / analogs & derivatives
  • Chi-Square Distribution
  • Chromatography, High Pressure Liquid
  • Creatinine / blood
  • Female
  • Humans
  • Kidney Failure, Chronic / therapy*
  • Male
  • Membranes, Artificial*
  • Methylmethacrylates*
  • Middle Aged
  • Molecular Weight
  • Peritoneal Dialysis, Continuous Ambulatory / standards
  • Renal Dialysis / standards*
  • Serum Albumin / metabolism
  • Software
  • Treatment Outcome
  • beta 2-Microglobulin / metabolism


  • Biocompatible Materials
  • Membranes, Artificial
  • Methylmethacrylates
  • Serum Albumin
  • beta 2-Microglobulin
  • acetylcellulose
  • Cellulose
  • Creatinine