Abstract
Keenamide A (1), a new cytotoxic cyclic hexapeptide, was isolated from the notaspidean mollusk Pleurobranchus forskalii. Its structure was determined by NMR spectral data interpretation and chiral amino acid analysis. Keenamide A (1) exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antimalarials / pharmacology
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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HT29 Cells
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Humans
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Mollusca / chemistry*
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Plasmodium falciparum / drug effects
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Spectrometry, Mass, Fast Atom Bombardment
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Tumor Cells, Cultured
Substances
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Antimalarials
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Antineoplastic Agents
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Peptides, Cyclic
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keenamide A