Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii

J Nat Prod. 1996 Jun;59(6):629-31. doi: 10.1021/np960153t.

Abstract

Keenamide A (1), a new cytotoxic cyclic hexapeptide, was isolated from the notaspidean mollusk Pleurobranchus forskalii. Its structure was determined by NMR spectral data interpretation and chiral amino acid analysis. Keenamide A (1) exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antimalarials / pharmacology
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • HT29 Cells
  • Humans
  • Leukemia P388 / drug therapy
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mollusca / chemistry*
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Plasmodium falciparum / drug effects
  • Spectrometry, Mass, Fast Atom Bombardment
  • Tumor Cells, Cultured

Substances

  • Antimalarials
  • Antineoplastic Agents
  • Peptides, Cyclic
  • keenamide A