BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation

Bioessays. 1996 Jun;18(6):439-42. doi: 10.1002/bies.950180604.


Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF-beta superfamily. Recent findings indicate that BMP-1 is identical to pro-collagen C-proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern formation during development. Taken together, current studies indicate that BMP-1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bone Morphogenetic Protein 1
  • Bone Morphogenetic Proteins
  • Cell Differentiation / physiology
  • Extracellular Matrix / physiology
  • Growth / physiology
  • Growth Substances / genetics
  • Growth Substances / physiology*
  • Humans
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / physiology*
  • Molecular Sequence Data
  • Proteins / genetics
  • Proteins / physiology*


  • Bone Morphogenetic Proteins
  • Growth Substances
  • Proteins
  • Metalloendopeptidases
  • BMP1 protein, human
  • Bone Morphogenetic Protein 1
  • astacin