Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

Neurosci Lett. 1995 Dec 29;202(1-2):17-20. doi: 10.1016/0304-3940(95)12192-7.


Interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) were measured in the cerebrospinal fluid (CSF) and plasma of 12 control subjects, 11 sporadic Alzheimer's disease (AD) and 22 de novo Parkinson's disease (PD) patients using high sensitivity enzyme-linked immunosorbent assays (ELISA). IL-1 beta and IL-6 contents were significantly elevated in the CSF of de novo PD and AD patients in comparison to the control group. In contrast, the plasma levels were not significantly affected. IL-2 contents in the CSF and plasma samples were unchanged in the three groups compared. Because the two cytokines IL-1 beta and IL-6 are known to play a key role in the interaction between the nervous and immune system, e.g. in the so-called acute phase response, our results support the involvement of immunological events in the complex process of neurodegeneration in AD and PD.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / cerebrospinal fluid*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-1 / blood
  • Interleukin-1 / cerebrospinal fluid*
  • Interleukin-2 / blood
  • Interleukin-2 / cerebrospinal fluid
  • Interleukin-6 / blood
  • Interleukin-6 / cerebrospinal fluid*
  • Male
  • Middle Aged
  • Parkinson Disease / cerebrospinal fluid*


  • Interleukin-1
  • Interleukin-2
  • Interleukin-6