TDT with covariates and genomic screens with mod scores: their behavior on simulated data

Genet Epidemiol. 1995;12(6):659-64. doi: 10.1002/gepi.1370120623.


We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Computer Simulation
  • Genetic Testing / methods*
  • Genetics, Population*
  • Genome, Human*
  • Genotype
  • Humans
  • Linkage Disequilibrium*
  • Lod Score*
  • Models, Genetic