5-HT1B receptor knock out--behavioral consequences

Behav Brain Res. 1996;73(1-2):305-12. doi: 10.1016/0166-4328(96)00119-2.


Serotonin is a neuromodulator that is involved in a number of mood disorders such as depression, anxiety and impulsive violence. In an attempt to dissect the contribution of individual 5-HT receptor subtypes to behavior, we have generated by homologous recombination, mutant mice lacking the 5-HT1B receptor. These mice did not exhibit any obvious developmental or behavioral defect. However, the hyperlocomotor effect of the 5-HT1A/1B agonist, RU 24969 was completely absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, isolated mutant mice attacked the intruder faster and more intensely than wild-type mice, suggesting an involvement of 5-HT1B receptors in the modulation of aggressive behavior. These data might be related to the fact that a class of 5-HT1 agonists, termed serenics, have anti-aggressive properties, and with the findings that certain impulsive aggressive behaviors are associated with deficits in central serotonin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggression / drug effects
  • Animals
  • Anxiety / psychology
  • Autoradiography
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Brain / anatomy & histology
  • Brain Chemistry / drug effects
  • Brain Chemistry / physiology
  • Female
  • Indoles / pharmacology
  • Male
  • Mice
  • Mice, Knockout
  • Motor Activity / drug effects
  • Rats
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / genetics*
  • Receptors, Serotonin / physiology*
  • Serotonin Receptor Agonists / pharmacology


  • Indoles
  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole