American Society is becoming increasingly diverse and multi-cultural. Nursing education must recognize the impact this has on our profession, education and care. A private southern university recently embraced culturalism as a conceptual thread in its curriculum and is providing cultural content to better prepare nursing students to provide culturally appropriate care. This study's purpose was to compare the cultural competence and confidence of senior nursing students who had received cultural content (N = 32) with those who had not received any cultural content (N = 33). The Bernal and Froman Cultural Self Efficacy Scale was used. Findings suggest students who received some cultural course content feel less competent and confident to provide culturally sensitive care than those who received no cultural course content.