Provocation tests versus 24-h pH and pressure measurements

Eur J Gastroenterol Hepatol. 1995 Dec;7(12):1141-6. doi: 10.1097/00042737-199512000-00003.


The diagnosis of the oesophageal origin of non-cardiac chest pain is still a matter of controversy. This review discusses the diagnostic accuracy of oesophageal provocation tests, such as acid perfusion, edrophonium and balloon distension, in comparison with 24-h intra-oesophageal pH and pressure recordings. It also discusses how these various tests relate to known underlying mechanisms of oesophageal chest pain: acid reflux, oesophageal dysmotility or a combination of both.

Publication types

  • Review

MeSH terms

  • Chest Pain / etiology
  • Esophageal Diseases / complications
  • Esophageal Diseases / diagnosis*
  • Esophagus / physiology
  • Humans
  • Hydrogen-Ion Concentration
  • Monitoring, Physiologic*
  • Peristalsis
  • Pressure
  • Reproducibility of Results
  • Sensitivity and Specificity