Kv beta 1 subunit binding specific for shaker-related potassium channel alpha subunits

Neuron. 1996 Feb;16(2):455-63. doi: 10.1016/s0896-6273(00)80063-x.


Voltage-activated potassium (Kv) channels from mammalian brain are hetero-oligomers containing alpha and beta subunits. Coexpression of Kv1 alpha and Kv beta 1 subunits confers rapid A-type inactivation on noninactivating potassium channels (delayed rectifiers) in expression systems in vitro. We have delineated a Kv1.5 aminoterminal region of up to 90 amino acids (residues 112-201) that is sufficient for interactions of Kv1.5 alpha and Kv beta 1 subunits. Within this region of the Kv1.5 amino terminus (residues 193-201), a Kv beta 1 interaction site necessary for Kv beta 1-mediated rapid inactivation of Kv1.5 currents was detected. This interaction site motif (FYE/QLGE/DEAM/L) is found exclusively in the Shaker-related subfamily (Kv1). The results show that hetero-oligomerization between alpha and Kv beta 1 subunits is restricted to Shaker-related potassium channel alpha subunits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Cell Line
  • Conserved Sequence
  • Drosophila / genetics*
  • Molecular Probes / genetics
  • Molecular Sequence Data
  • Mutation*
  • Potassium Channels / genetics*
  • Potassium Channels / metabolism*


  • Molecular Probes
  • Potassium Channels

Associated data

  • GENBANK/M27158
  • GENBANK/M59980
  • GENBANK/X62841