Marked Hepatotoxicity Associated With Losartan Treatment

Blood Press. 1996 May;5(3):190-1. doi: 10.3109/08037059609062128.


Losartan represent a novel approach in the treatment of hypertension. Clinical trials have reported a very low incidence of side effects. We describe two patients who developed increases in alanine/aspartate amino transferase of 8 and 15 times the upper normal limit, as well as thoracic pain, after a short time of treatment with losartan. The increase resolved after discontinuing losartan treatment.

Publication types

  • Case Reports

MeSH terms

  • Angiotensin Receptor Antagonists*
  • Antihypertensive Agents / adverse effects*
  • Biphenyl Compounds / adverse effects*
  • Female
  • Humans
  • Imidazoles / adverse effects*
  • Liver / drug effects*
  • Losartan
  • Middle Aged
  • Tetrazoles / adverse effects*


  • Angiotensin Receptor Antagonists
  • Antihypertensive Agents
  • Biphenyl Compounds
  • Imidazoles
  • Tetrazoles
  • Losartan