Protein tyrosine phosphatases in signaling

Curr Opin Cell Biol. 1996 Apr;8(2):182-8. doi: 10.1016/s0955-0674(96)80064-0.


During the past few years, molecular cloning has established the existence of a structurally diverse family of intracellular and transmembrane protein tyrosine phosphatases (PTPases). The importance of PTPases in signaling is best understood in three model systems: the mammalian transmembrane CD45 PTPase, the Drosophila Src homology (SH)2 domain containing corkscrew PTPase and its vertebrate homolog SH-PTP2, and the mouse SH2-domain-containing hematopoietic cell PTPase. Whereas CD45, corkscrew and SH-PTP2 positively regulate tyrosine phosphorylation, the hematopoietic cell PTPase negatively regulates or terminates signaling. Recent data indicate that several transmembrane PTPases mediate cell adhesion, suggesting that they effect adhesion-specific signaling events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Humans
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / physiology*


  • Protein-Tyrosine Kinases