Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

Curr Opin Cell Biol. 1996 Apr;8(2):146-52. doi: 10.1016/s0955-0674(96)80059-7.


Integrin signalling requires the activation of protein tyrosine kinases and members of the Rho family of small GTP-binding proteins. Recent evidence shows that coordinated regulation of these signalling molecules is central to the control of cell adhesion, formation of the actin cytoskeleton and activation of intracellular signalling cascades.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Down-Regulation
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Integrins / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / physiology*


  • Integrins
  • Protein-Tyrosine Kinases
  • GTP-Binding Proteins