Regulation of transcription by MAP kinase cascades

Curr Opin Cell Biol. 1996 Apr;8(2):205-15. doi: 10.1016/s0955-0674(96)80067-6.


Kinases belonging to the mitogen-activated protein kinase (MAPK) family are used throughout evolution to control the cellular responses to external signals such as growth factors, nutrient status, stress or inductive signals. Many important substrates for MAPKs are transcription factors, and both the genetic and the biochemical links between MAPKs and transcription factors are becoming increasingly well understood.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Phosphorylation
  • Transcription Factors / metabolism
  • Transcription, Genetic / physiology*


  • Transcription Factors
  • Calcium-Calmodulin-Dependent Protein Kinases