Signal transduction through lipid second messengers

Curr Opin Cell Biol. 1996 Apr;8(2):159-67. doi: 10.1016/s0955-0674(96)80061-5.


This review emphasizes the generation of glycerolipid and sphingolipid second messengers, and their molecular targets. The role of the phosphatidylinositol transfer protein and phospholipase D in signal transmission, and the structures of the 1, 2-diacylglycerol and calcium-binding sites of protein kinase C are discussed. Further, ceramide signaling through protein kinases and the role of cross-talk in the signaling of apoptosis and inflammation are addressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Lipids / physiology*
  • Second Messenger Systems / physiology*
  • Signal Transduction* / physiology
  • Sphingolipids / physiology


  • Lipids
  • Sphingolipids