Heterotrimeric G proteins

Curr Opin Cell Biol. 1996 Apr;8(2):189-96. doi: 10.1016/s0955-0674(96)80065-2.


Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in stimulation of a variety of effectors following receptor activation; and fourth, identification of the points of contact among the Galpha, Gbeta, and Ggamma subunits, and between these subunits and their cognate receptor or effector molecules.

Publication types

  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / metabolism*
  • Guanosine Triphosphate / metabolism
  • Humans
  • Hydrolysis
  • Molecular Structure


  • Guanosine Triphosphate
  • GTP-Binding Proteins