Approaching the mechanism of protein transport across the ER membrane

Curr Opin Cell Biol. 1996 Aug;8(4):499-504. doi: 10.1016/s0955-0674(96)80027-5.


Since the identification of essential protein-translocation components in the endoplasmic reticulum membrane, research efforts have concentrated on the elucidation of the molecular mechanism of protein transport across this membrane. Recent results have provided new information as to how proteins are targeted to, and inserted into, the translocation site during translation. Post-translational translocation has also been examined and is distinct from cotranslational translocation with respect to the mechanism and membrane protein components involved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biological Transport
  • Endoplasmic Reticulum / metabolism*
  • Models, Biological
  • Protein Biosynthesis
  • Protein Processing, Post-Translational
  • Proteins / metabolism*


  • Proteins