From DNA damage to cell cycle arrest and suicide: a budding yeast perspective

Curr Opin Genet Dev. 1996 Feb;6(1):4-11. doi: 10.1016/s0959-437x(96)90003-9.

Abstract

Eukaryotic checkpoint control genes are important for cell cycle delay, DNA repair and cell suicide after DNA is damaged. Recent studies in budding yeast show how the participation of checkpoint control proteins in DNA metabolism could lead to all three of these outcomes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Death / physiology*
  • DNA Damage / physiology*
  • DNA Repair*
  • Eukaryotic Cells / physiology
  • G2 Phase / physiology
  • Humans
  • Mammals / physiology
  • Mitosis / physiology
  • Proteins / metabolism
  • S Phase / physiology
  • Schizosaccharomyces / physiology
  • Signal Transduction / physiology*
  • Yeasts / physiology*

Substances

  • Proteins