Genetics of infectious disease resistance

Curr Opin Genet Dev. 1996 Jun;6(3):348-53. doi: 10.1016/s0959-437x(96)80013-x.


The identification of large numbers of candidates genes and the introduction of methodologies for whole-genome screening have provided new opportunities for elucidating the molecular basis of variable susceptibility to major infectious diseases. 12 genes have been implicated in variable susceptibility to malaria and susceptibility/resistance genes for several other infectious diseases are beginning to be identified. Recent work suggests that large-scale family linkage and population association studies will be a more successful route to human disease genes than extrapolation from mouse models of infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Communicable Diseases / genetics*
  • Genetic Linkage
  • Humans
  • Immunity, Innate / genetics*