Conservation of dorsal-ventral patterning in arthropods and chordates

Curr Opin Genet Dev. 1996 Aug;6(4):424-31. doi: 10.1016/s0959-437x(96)80063-3.

Abstract

Dorsal-ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been conserved over 500 million years of evolution. In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. A second Xenopus gene, noggin, has a similar biological activity to chordin. Analysis of the action of these genes indicate that Spemann's organizer promotes dorsal cell fates in Xenopus by antagonizing a ventralizing signal encoded by the Bmp4 gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 4
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism
  • Carrier Proteins
  • Drosophila / embryology*
  • Drosophila / genetics*
  • Drosophila / metabolism
  • Drosophila Proteins*
  • Ectoderm
  • Glycoproteins*
  • Growth Substances / genetics
  • Growth Substances / metabolism
  • Humans
  • Insect Proteins / genetics
  • Insect Proteins / metabolism
  • Intercellular Signaling Peptides and Proteins*
  • Mesoderm
  • Proteins / genetics
  • Proteins / metabolism
  • Signal Transduction
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism
  • Xenopus / embryology*
  • Xenopus / genetics*
  • Xenopus / metabolism
  • Xenopus Proteins
  • Zygote

Substances

  • BMP4 protein, human
  • Bone Morphogenetic Protein 4
  • Bone Morphogenetic Proteins
  • Carrier Proteins
  • Drosophila Proteins
  • Glycoproteins
  • Growth Substances
  • Insect Proteins
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Transforming Growth Factor beta
  • Xenopus Proteins
  • bmp4 protein, Xenopus
  • dpp protein, Drosophila
  • sog protein, Drosophila
  • noggin protein
  • chordin