Dosage compensation and chromatin structure in Drosophila

Curr Opin Genet Dev. 1996 Aug;6(4):496-501. doi: 10.1016/s0959-437x(96)80073-6.


The past year has brought significant advances in our understanding of the male-specific lethal (msl genes and dosage compensation in Drosophila. The molecular characterization of the msl-2 gene has, to a great extent, solved the question of how msl-mediated dosage compensation is restricted to males. Molecular analyses of the msl genes have substantiated the proposal that the MSL proteins function as a multimeric complex to mediate dosage compensation. The finding that MSL-2 protein has a RING finger and the demonstration that an insulator protein facilitates the dosage compensation of X-linked genes inserted into the autosomes have opened promising avenues to identify the cis-acting dosage-compensation determinants.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Animals
  • Choristoma
  • Chromatin*
  • Chromosomal Proteins, Non-Histone*
  • DNA Helicases*
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Dosage Compensation, Genetic*
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Evolution, Molecular
  • Gene Expression
  • Histones
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • RNA-Binding Proteins / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • X Chromosome
  • Zinc Fingers / genetics*


  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Histones
  • Nuclear Proteins
  • RNA-Binding Proteins
  • Transcription Factors
  • mle protein, Drosophila
  • msl-2 protein, Drosophila
  • DNA Helicases