Assays of omeprazole metabolism as a substrate probe for human CYP isoforms

Methods Enzymol. 1996:272:132-9. doi: 10.1016/s0076-6879(96)72016-5.

Authors

D J Birkett¹, T Andersson, J O Miners

Affiliation

¹ Department of Clinical Pharmacology, Flinders University of South Australia, Bedford Park.

PMID: 8791770
DOI: 10.1016/s0076-6879(96)72016-5

No abstract available

MeSH terms

Aryl Hydrocarbon Hydroxylases*
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System / analysis
Cytochrome P-450 Enzyme System / metabolism*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / metabolism
Enzyme Inhibitors / pharmacokinetics
Humans
In Vitro Techniques
Kinetics
Microsomes, Liver / enzymology
Mixed Function Oxygenases / analysis
Mixed Function Oxygenases / metabolism
Molecular Probes
Omeprazole / chemistry
Omeprazole / metabolism*
Omeprazole / pharmacokinetics
Proton Pump Inhibitors

Substances

Enzyme Inhibitors
Molecular Probes
Proton Pump Inhibitors
Cytochrome P-450 Enzyme System
Mixed Function Oxygenases
Aryl Hydrocarbon Hydroxylases
CYP2C19 protein, human
CYP3A protein, human
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP3A
Omeprazole